Hypernatremia for USMLE Step 2

Share this & earn $10
the study spot
Published at : 05 Feb 2021
25541 views
267
14

Hypernatremia is defined as a serum sodium concentration of greater than 145 mmol/L. By definition this is also known as a hyperosmolar state.

PHYSIOLOGY of SODIUM
There are three spaces known as the intravascular, interstitial and intracellular space. Fluid is distributed throughout this entire area. The fluid present in the intravascular and interstitial space is known as the extracellular fluid (ECF). Within this area the fluid freely moves and there is not affect on changes electrolyte concentration. The intracellular fluid is twice the volume of extracellular space.

The movement of water is always towards the direction of the highest solute. In the intravascular space, the sodium has the strongest affect on water to move water towards the vascular space. So high sodium will cause increase water in the intravascular space, while low sodium decreases the amount of sodium in the intravascular space. Glucose and urea also have the same effect. Therefore the plasma osmolality is determined by 2xNa+Glucose/18+BUN/2.8 which is normally between 270-290. BUN is known as the ineffective osmole because it can move freely into the cell and therefore it can't push water in any direction. The tonicity is the same as plasma osmolality except BUN is not taken into the consideration.

PATHOPHYSIOLOGY OF HYPERNATREMIA
Either due to loss of total body water or increase in sodium. Normally osmoreceptors in hypothalamus get activated (280-290 mosmol/L). This leads to increasing thirst and ADH.

Regulation of brain volume is important to consider with looking at the pathology. During hypernatremia, acutely the neuron will lose water and lead to dehydration. After some time electrolytes move into cell and the water follows leading to partial restoration. Chronically (after 2 days) there is movement of oraganic osmolytes (AA, polyol, mehtylamine) and this can cause the brain cell to return to normal size.

ETIOLOGY AND CAUSES OF HYPERNATREMIA
Hypovolemic hypernatremia occurs when there is loss of water and sodium. Non-renal causes will have urine sodium less than 10. This is most commonly associated with sweating, osmotic diarrhea, decreased water drinking and thirst, which is most common cause of hypernatremia in elderly and debilitated. In these patients the urine osmolality is greater than 800. Pancreatitis, burns and trauma may also cause these. Renal causes will have a urine sodium greater than 10 caused by excessive diuretic use (mannitol), adipsic diabetes insipidus, septor optic dysplasia, brain tumor.

Hypervolemic hypernatremia occurs when there is sodium retention. Non renal the FeNa is greater than 2%. Iatrogenic causes associated with sodium bicarbonate during metabolic acidosis. Hydatid cyst treatment, abortion and salt poisoning may lead to hypernatremia. Renal causes has a FeNa less than1% and caues by hyperaldosteronism.

Euvolemia is loss of sodium without water. Common causes is diabetes inspidus and hypothyroidism.

CLINICAL SIGNS AND SYMPTOMS of hypernatremia
Acute is less than 48 hours. There is rapid decrease in rapid decrease in brain volume leading to rupture of cerebral veins and demyelinating brain lesions. Symptoms initially present as lethargy, weakness, irritability, obtundation, decrease level of concsiousness, seizure, coma and eventual death.

Chronic is defined as hypernatremia lasting longer than 48 hours. Since it is occuring more slowly the brain is able to adapt to these changes.

INVESTIGATIONS for hypernatremia.
Serum electrolytes and osmolarity, glucose, urea, creatine and ADH.
Urine electrolytes, omsolarity, urine volume over 24 hours.
CT/MRI is important if considering Diabetes Insipidus.

TREATMENT of hypernatremia
3ml H20/kg will decrease sodium 1meq/L
Chronic hypernatremia should be correct slowly because the brain has adjusted to the change in sodium and may lead to brain edema. Decrease serum sodium less than 10meq/day. Any faster than this speed may lead to cerebral edema. IV destrose 5% water at a rate of 1.35/ml/hr/kg and monitor every 4-6 hours.

Acute hypernatremia requires rapid adjustment and so need to prevent any neurological damage. Generally reach normal sodium wihtin 24 hours. IV Dextrose 5% water 3 6ml/hr/kg and monitor every 1 to 2 hours until sodium is below 145 meq/L. Then give 1-2meq/L/hr until restored.

Water defecit is calculated by TBW x (serumNa/140 -1). TBW is generally 60/55% in young adult and 50/45% in elderly and even less if obese. Replace ongoing water loss such as sweat and stool (30-50ml/hr) and urine.
USMLE Step 1Hypernatremia (Disease Or Medical Condition)USMLE Step 2 Clinical Knowledge

I've Been Thinking of You| | Eye Language | Documentary About Emotions

I've Been Thinking of You| | Eye Language | Documentary About Emotions

They Didn't Even breath OMG Сидоджи Дубоshit и Грязный Рамирес Джин Grey Grey (Reaction)

They Didn't Even breath OMG Сидоджи Дубоshit и Грязный Рамирес Джин Grey Grey (Reaction)

Necessary vs Elevate | Fuga Tournament - Standoff 2

Necessary vs Elevate | Fuga Tournament - Standoff 2

Kendrick Lamar Producer Makes A Beat ON THE SPOT - Focus... ft MICXSIC

Kendrick Lamar Producer Makes A Beat ON THE SPOT - Focus... ft MICXSIC

Scottish Fold gives birth to 4 cute kittens | Pregnant Silver Cat giving birth to adorable baby cats

Scottish Fold gives birth to 4 cute kittens | Pregnant Silver Cat giving birth to adorable baby cats

10 Black Friday Shopping Secrets Amazon Doesn’t Want You to Know!

10 Black Friday Shopping Secrets Amazon Doesn’t Want You to Know!

The Normal Distribution and the 68-95-99.7 Rule (5.2)

The Normal Distribution and the 68-95-99.7 Rule (5.2)

Learn About Professions for Children - Learn Jobs for Kids - English Vocabulary - Educational video

Learn About Professions for Children - Learn Jobs for Kids - English Vocabulary - Educational video

Bob Dylan Cover - Most Likely You Go Your Way (And I'll go mine) - Pete Stark

Bob Dylan Cover - Most Likely You Go Your Way (And I'll go mine) - Pete Stark

Visa vs. Mastercard

Visa vs. Mastercard

Madonna - You'll See

Madonna - You'll See

I migliori broker 2021 per investire e fare trading | La guida completa definitiva

I migliori broker 2021 per investire e fare trading | La guida completa definitiva

The World's Most Dangerous Approach - Paro, Bhutan

The World's Most Dangerous Approach - Paro, Bhutan

२ महिना पछि राजु परियार इन्द्रेणीमा सुनितामी परियार सँग साह्रै उत्कृष्ठ दोहोरी । ०५.१०.०७७।। HD

२ महिना पछि राजु परियार इन्द्रेणीमा सुनितामी परियार सँग साह्रै उत्कृष्ठ दोहोरी । ०५.१०.०७७।। HD

COVID-19 measures on Public Transport| NBS Up and About

COVID-19 measures on Public Transport| NBS Up and About

Warzone: NEW DMR-14 & MAC-10 NERF... But was it enough?

Warzone: NEW DMR-14 & MAC-10 NERF... But was it enough?

HOW TO GET THE NEW *GODLY BANANA COW* IN OVERLOOK BAY! Roblox Overlook Bay Update

HOW TO GET THE NEW *GODLY BANANA COW* IN OVERLOOK BAY! Roblox Overlook Bay Update

FDA proposes a set of e-cigarette rules in an effort to curb teen vaping

FDA proposes a set of e-cigarette rules in an effort to curb teen vaping

Forced lock down

Forced lock down

Learn English grammar | Few and a few

Learn English grammar | Few and a few

the deck clash royale it is very good and battle it is hard #1

the deck clash royale it is very good and battle it is hard #1

jungkook making sure jimin eats well

jungkook making sure jimin eats well

Kim Maverick - Way Of Living (Official Video Clip)

Kim Maverick - Way Of Living (Official Video Clip)

10 Websites That Will Pay You DAILY Within 24 hours! (Easy Work At Home Jobs)

10 Websites That Will Pay You DAILY Within 24 hours! (Easy Work At Home Jobs)

Engaged at 19 / What’s next? *TEEN PARENTS ENGAGEMENT Q&A*

Engaged at 19 / What’s next? *TEEN PARENTS ENGAGEMENT Q&A*

THIS CLUTCH MIGHT GET ME SIGNED TO 100T! COD: Warzone Gameplay

THIS CLUTCH MIGHT GET ME SIGNED TO 100T! COD: Warzone Gameplay

THE STORY OF 50 MONETISED CHANNEL 2020

THE STORY OF 50 MONETISED CHANNEL 2020

PUBG P32 Customs - Teaming is Encouraged

PUBG P32 Customs - Teaming is Encouraged

TUTORIAL: Beethoven's "Moonlight" (3rd movt.) at Five Progressively Increasing Tempos

TUTORIAL: Beethoven's "Moonlight" (3rd movt.) at Five Progressively Increasing Tempos

all at once「JUST BELIEVE YOU」(TVアニメ「名探偵コナン」オープニングテーマ)

all at once「JUST BELIEVE YOU」(TVアニメ「名探偵コナン」オープニングテーマ)

The Cheater's Guide to Counterpoint

The Cheater's Guide to Counterpoint

Fix Android Obtaining WiFi Address, Cant Connect to Internet

Fix Android Obtaining WiFi Address, Cant Connect to Internet

The Art of Stopping

The Art of Stopping

BARISTA TRAINING SERIES - Part 2 -  Open and Close Procedure

BARISTA TRAINING SERIES - Part 2 - Open and Close Procedure

What a faithful God have I

What a faithful God have I

What is a focus keyphrase? | Yoast SEO for WordPress

What is a focus keyphrase? | Yoast SEO for WordPress

Fortnite Dance Battle Of All Golden Skins

Fortnite Dance Battle Of All Golden Skins

If you TRY them you WILL buy them!

If you TRY them you WILL buy them!

WATCH: Bison charges 9-year-old girl at Yellowstone National Park

WATCH: Bison charges 9-year-old girl at Yellowstone National Park

We're here for supporting local so that they’re here to stay

We're here for supporting local so that they’re here to stay

Every NBA Team's Most Embarrassing Turnover!

Every NBA Team's Most Embarrassing Turnover!

Patty Loveless, George Jones - You Don't Seem to Miss Me (Video)

Patty Loveless, George Jones - You Don't Seem to Miss Me (Video)

Hips, Pelvis, Legs, Spine — This Practice is 5 Movements

Hips, Pelvis, Legs, Spine — This Practice is 5 Movements

Europe - Carrie (Official Video)

Europe - Carrie (Official Video)

Let's Learn English Around the House and Home | English Video with Subtitles

Let's Learn English Around the House and Home | English Video with Subtitles

Control Ultimate Edition: Complete Power

Control Ultimate Edition: Complete Power

Top 10 WORST FAMILY MEMBERS! (Mom Sells Son, Dad Embarrasses Kid)

Top 10 WORST FAMILY MEMBERS! (Mom Sells Son, Dad Embarrasses Kid)

Simon Sinek's - 5 Minutes on Why COVID-19 Is An Opportunity

Simon Sinek's - 5 Minutes on Why COVID-19 Is An Opportunity

Dido - You Don't Need A God (Official Audio)

Dido - You Don't Need A God (Official Audio)